To make a poison from mundane ingredients is hard. Prices and DC for poison bases:
|Type||Craft DC||price per dose||Onset||Frequency|
These base poisons have DC 11, 1 save to cure, take effect at most 6 times, and do 1 dmg to a physical attribute (str, dex, con) of the crafter’s choice.
You can also start with poisons found in nature, foraging for them with a Knowledge (Nature) check. These have various stats, and are generally more effective than synthetic base poisons, but are almost always ingested poisons.
Once you have a base poison, you can try to improve it in various ways. This requires a further craft check, and the better the check the more potent the result. The process always takes 1 day, you can work on up to 6 doses at a time, regardless of the check result. Any given alchemist can only improve each dimension of a given dose once. Failure by 5 or more ruins the base poison. You can take 10.
You can improve:
|Save DC||Craft DC|